Summary of published evidence

Evidence on health care worker-managed groups highlights improved client outcomes, both at individual sites and at scale, and suggests benefits to specific client populations, including children, their caregivers and adolescents. The majority of evidence for health care worker-managed group models comes from implementation of the ART adherence club (AC) model in Cape Town, South Africa. Details of the model expansion highlight that from January 2011 to March 2015, 32,425 clients were in an AC (25.2% of the total ART cohort). Fifty-five facilities were offering a total of 1,308 ACs (1). In a cluster random sample of 10% of the Cape Town ACs (3,216 adults) from non-research supported ART sites, retention was 95.2% (CI 94-96.4) at 12 months and 89.3% (CI 87.1-91.4) at 24 months. In the 13 months prior to database closure, 88.1% of clients had viral loads (VL) taken with VL ≤400 copies/ml in 97.2% (CI 96.5-97.8) (2). An evaluation of disengagement from care in Khayelitsha, Western Cape reported AC participation as highly protective against disengagement (hazard ratio: 0.27 (0.24-0.30) (3).

Two comparison cohort studies report client outcomes from ACs (4, 5). In the pilot study in Khayelitsha, Cape Town, retention at study end was 97% for those stable clients who enrolled in an AC versus 85% for those who did not. LTFU was reduced by 57% (hazard ratio, HR, 0.43, 95% CI 0.21-0.91) and viral rebound by 67% (HR 0.33, 95% CI 0.16-0.67) (4). In Gugulethu, Cape Town, 94% were retained at 12 months post AC enrolment, with 3% experiencing viral rebound by study end (5). After adjustment, AC participation was associated with a 67% reduction in the risk of LTFU (aHR: 0.33, 95% CI: 0.27-0.40) compared with clients in the standard of care. A costing study found the Khayelitsha piloted AC model cost effective with a cost per patient year of $300 versus $374 for standard of care (6).

Four studies have described various aspects of the AC model. The first describes the AC model and the strategy used by local health authorities to scale out the model (7). The second describes the quality improvement approach embedded in the scale-out strategy (8). The third describes the adjusted AC model implemented in Gugulethu, where ACs were run at a community venue instead of the clinic (9). The fourth was a qualitative study exploring the perceptions of AC members and non-members at two sites in Khayelitsha and Gugulethu, Cape Town (10). The Western Cape AC model changed from providing 2-monthly ART refills (6 times a year) to providing a 4-monthly ART refill at year end (5 total visits per year) to accommodate year-end holiday migration. A comparison study found no difference in short-term retention or viral rebound risk comparing clients who receive 2 months versus 4 months of ART over the holiday period (11)

Research from Swaziland reported outcomes where health facilities were offered a choice of three ART delivery models for implementation. One health centre chose to implement ACs, 12 clinics implemented community ART groups (CAGs) and one health centre and one clinic implemented an outreach service to support remote communities. Twelve-month retention was 96% in ACs (n=289), 81% in CAGs (n=336) and 77% for the outreach service model (n=102) (12)

Three small studies from Cape Town, South Africa reported outcomes for specific populations: youth, children and their caregivers and post-natal women receiving their care from youth-specific ACs, family ACs or adults ACs respectively and one study reported outcomes for clients enrolled in adult ACs who had recently re-suppressed after a viral rebound episode. For youth ACs, ART client outcomes were good. Retention at 12 months for youth stable on ART was 94.3% (CI 85.4-96.8); for youth newly initiated on ART, it was 86.4% (CI 78.7-91.4); and for youth ineligible for ART, it was 52.9% (CI 40.0-64.2) (13). For family ACs, child and caregiver retention was 93.7% (CI 88.7 – 96.6) and 93.9% (CI 85.9 – 97.4) at 12 months and 86.1 (CI 79.5 – 90.8) and 89.7 (CI 80.4 – 94.8) at 36 months (14). For women initiated on ART during pregnancy, who chose to join an existing community-based adult AC immediately post-delivery (84/129; 65%), had similar retention and VL suppression outcomes 6 months post-partum as those women who chose to receive their care at the ART clinic (15). For patients who had re-suppressed after a nurse-led intervention and were immediately referred into an adult AC, 12-month retention and viral suppression after AC enrolment was 94.8% (CI 89.8-97.4) and 85.2% (CI 78.0-90.1), respectively (16).  

Two early studies have evaluated medication adherence clubs (MACs) which adjusted the AC model to incorporate stable hypertension or diabetic patients. A retrospective descriptive study of 1432 patients in MACs reported LTFU in the first year after enrolment of 3.5% (17). A qualitative study found the model acceptable to both patients and healthcare workers saving patients time and reducing queues at the clinic (18).


  1. Wilkinson L, Harley B, Sharp J, Solomon S, Jacobs S, Cragg C, Kriel E, Peton N, Jennings K, Grimsrud A. Expansion of the Adherence Club model for stable antiretroviral therapy patients in the Cape Metro, South Africa 2011–2015. Tropical Medicine & International Health. 2016 Jun 1;21(6):743-9.
  2. Tsondai P, Wilkinson L, Grimsrud A, Mdlalo P, Ullauri A, Boulle A. High rates of retention and viral suppression in the scale-up of anti-retroviral therapy adherence clubs in Cape Town, South Africa. Journal of International AIDS Society. 2017;20(Suppl 4):21649.
  3. Kaplan S, Oosthuizen C, Stinson K, Little F, Euvrard J, Osler M, et al. Contemporary disengagement from antiretroviral therapy in Khayelitsha, South Africa.  24th Conference on Retroviruses and Opportunistic Infections, Seattle, 13-16 February2017.
  4. Luque-Fernandez MAVC, G.; Goemaere, E.; Hilderbrand, K.; Schomaker, M.; Mantangana, N.; Mathee, S.; Dubula, V.; Ford, N.; Hernan, M. A.; Boulle, A. Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa. PLoS One. 2013;8(2):e56088.
  5. Grimsrud A, Lesosky M, Kalombo C, Bekker L-G, Myer L. Implementation and Operational Research: Community-Based Adherence Clubs for the Management of Stable Antiretroviral Therapy Patients in Cape Town, South Africa: A Cohort Study. Journal of Acquired Immune Deficiency Syndromes. 2016;71(1):e16-e23.
  6. Bango F, Ashmore J, Wilkinson L, Cutsem G, Cleary S. Adherence clubs for long‐term provision of anti‐retroviral therapy: Cost‐effectiveness and access analysis from Khayelitsha, South Africa. Tropical Medicine & International Health. 2016.
  7. Wilkinson LS. ART adherence clubs: A long-term retention strategy for clinically stable patients receiving antiretroviral therapy. Southern African Journal of HIV Medicine. 2013;14(2):48-50.
  8. Horwood CM, Youngleson MS, Moses E, Stern AF, Barker PM. Using adapted quality-improvement approaches to strengthen community-based health systems and improve care in high HIV-burden sub-Saharan African countries. AIDS. 2015;29:S155-S64.
  9. Grimsrud A, Sharp J, Kalombo C, Bekker L-G, Myer L. Implementation of community-based adherence clubs for stable antiretroviral therapy patients in Cape Town, South Africa. Journal of the International AIDS Society. 2015;18(1).
  10. Venables E, Towriss C, Rini Z, Nxiba X, Solomon S, Cassidy T, et al. "If I'm not in the club, I have to move from one chair to another", A qualitative evaluation of patient experiences of adherence clubs in Khayelitsha and Gugulethu, South Africa. 9th International AIDS Society Conference on HIV Science, Paris, 22-27 July 2017.
  11. Grimsrud A, Patten G, Sharp J, Myer L, Wilkinson L, Bekker LG. Extending dispensing intervals for stable patients on ART. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2014 Jun 1;66(2):e58-60.
  12. Pasipamire L, Kerschberger B, I. Zabsonre I, Ndlovu S, Sibanda G, Mamba S, et al. Implementation of combination ART refills models in rural Swaziland. International AIDS Conference, Durban, 18-22 July 2016.
  13. Wilkinson L, Moyo F, Henwood R, Runeyi P, Patel S, de Azevedo V, et al. Youth ART adherence clubs: Outcomes from an innovative model for HIV positive youth in Khayelitsha, South Africa. 21st International AIDS Conference, Durban, 18-22 July 2016.
  14. Tsondai P, Wilkinson L, Henwood R, Ullauri A, Cassidy T, Tutu S, et al. Retention and viral suppression outcomes of patients enrolled in family ART adherence clubs in Cape Town, South Africa. 9th International AIDS Society Conference on HIV Science, Paris, 22-27 July 2017.
  15. Myer L, Lyun V, Zerbe A, Phillips TK, Brittain K, Mukonda E, et al. Differentiated models of care for postpartum women on antiretroviral therapy in Cape Town, South Africa: a cohort study. Journal of International AIDS Society. 2017;20(Suppl 4):21636.
  16. Sharp J, Wilkinson L, Cox V, Cragg C, van Cutsem G, Grimsrud A. Outcomes of patients enrolled in ART adherence clubs after viral re-suppression Conference on Retroviruses and Opportunistic Infections, Boston, 22-25 February 2015.
  17. Khabala KB, Edwards JK, Baruani B, Sirengo M, Musembi P, Kosgei RJ, et al. Medication Adherence Clubs: a potential solution to managing large numbers of stable patients with multiple chronic diseases in informal settlements. Tropical Medicine & International Health. 2015;20(10):1265-70
  18. Venables E, Edwards JK, Baert S, Etienne W, Khabala K, Bygrave H. " They just come, pick and go." The Acceptability of Integrated Medication Adherence Clubs for HIV and Non Communicable Disease (NCD) Patients in Kibera, Kenya. PloS one. 2016;11(10):e0164634